Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Il13. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Il13
  • participates in the following biological processes:
    • cellular response to cytokine stimulus ^[2]
  • is located in the following cellular components:
    • cytoplasm ^[10]
    • external side of plasma membrane ^{[2, 8]}
    • extracellular space ^{[1, 3, 5, 6, 7, 9]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Il13
  • participates in the following biological processes:
    • positive regulation of macrophage activation ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Il13:
  • participates in the following biological processes:
    • negative regulation of transforming growth factor beta production
    • positive regulation of B cell proliferation
    • positive regulation of connective tissue growth factor production
    • positive regulation of immunoglobulin production
    • positive regulation of ion transport
    • positive regulation of pancreatic stellate cell proliferation
    • positive regulation of protein secretion
    • positive regulation of release of sequestered calcium ion into cytosol
    • positive regulation of smooth muscle cell proliferation
    • positive regulation of tyrosine phosphorylation of Stat6 protein
    • regulation of proton transport
    • response to nicotine
  • performs the following molecular functions:
    • interleukin-13 receptor binding
  • is located in the following cellular components:
    • extracellular region
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Il13 encodes a protein or proteins that contain the following InterPro domains: Four-helical cytokine, core, Four-helical cytokine-like, core, Interleukin-13, Interleukin-4/interleukin-13, Interleukin-4/interleukin-13, conserved site, indicating that the gene product:
  • participates in the following biological processes:
    • immune response
  • performs the following molecular functions:
    • cytokine receptor binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Il13 indicates that it:
  • performs the following molecular functions:
    • cytokine activity

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References

1. Dardalhon V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol, 9:1347-55. (PubMed:18997793)
2. Guo L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A, 106:13463-8. (PubMed:19666510)
3. Kim PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol, 177:6650-9. (PubMed:17082577)
4. Kurowska-Stolarska M et al. (2009) IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J Immunol, 183:6469-77. (PubMed:19841166)
5. Lin W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol, 116:1106-15. (PubMed:16275384)
6. McKee AS et al. (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol, 173:1224-31. (PubMed:15240714)
7. Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol, 12:450-9. (PubMed:21460847)
8. van Hamburg JP et al. (2008) Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur J Immunol, 38:2573-86. (PubMed:18792410)
9. Watanabe T et al. (2006) Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity, 25:473-85. (PubMed:16949315)
10. Zourbas S et al. (2001) Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the foetomaternal interface during murine pregnancy. Clin Exp Immunol, 126:519-28. (PubMed:11737071)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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