Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits fibronectin binding activity and insulin-like growth factor binding activity. Involved in several processes, including osteoblast differentiation; positive regulation of signal transduction; and type B pancreatic cell proliferation. Localizes to extracellular space. Is expressed in several structures, including alimentary system; brain; early embryo; gonad; and limb. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).