Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hspd1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 11, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Hspd1
  • participates in the following biological processes:
    • positive regulation of interferon-alpha production ^[11]
    • positive regulation of interferon-gamma production ^{[11, 12]}
    • positive regulation of T cell activation ^[11]
    • T cell activation ^{[11, 12, 13]}
  • performs the following molecular functions:
    • lipopolysaccharide binding ^[11]
  • is located in the following cellular components:
    • cytoplasm ^[4]
    • intracellular membrane-bounded organelle ^{[6, 15]}
    • mitochondrial inner membrane ^[7]
    • mitochondrion ^{[2, 3, 5, 8, 9, 10, 14]}
    • plasma membrane part ^[1]
    • secretory granule ^{[2, 3]}
• Researchers have inferred, based on genetic interactions, that the gene product of Hspd1
  • participates in the following biological processes:
    • positive regulation of interferon-gamma production based on interactions with Ifnar1 ^[11]
    • T cell activation based on interactions with Ifnar1 ^[11]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Hspd1:
  • participates in the following biological processes:
    • activation of cysteine-type endopeptidase activity involved in apoptotic process
    • B cell activation
    • B cell cytokine production
    • B cell proliferation
    • chaperone mediated protein folding requiring cofactor
    • detection of misfolded protein
    • isotype switching to IgG isotypes
    • MyD88-dependent toll-like receptor signaling pathway
    • negative regulation of apoptotic process
    • negative regulation of neuron apoptotic process
    • positive regulation of apoptotic process
    • positive regulation of inflammatory response
    • positive regulation of interferon-alpha production
    • positive regulation of interferon-gamma production
    • positive regulation of interleukin-10 production
    • positive regulation of interleukin-12 production
    • positive regulation of interleukin-6 production
    • positive regulation of macrophage activation
    • positive regulation of T cell activation
    • positive regulation of T cell mediated immune response to tumor cell
    • protein refolding
    • protein stabilization
    • response to unfolded protein
    • T cell activation
  • performs the following molecular functions:
    • cell surface binding
    • chaperone binding
    • insulin binding
    • lipopolysaccharide binding
    • misfolded protein binding
    • p53 binding
    • protease binding
    • protein complex binding
    • protein heterodimerization activity
  • is located in the following cellular components:
    • cell surface
    • coated pit
    • coated vesicle
    • cytoplasm
    • cytosol
    • early endosome
    • extracellular space
    • Golgi apparatus
    • lipopolysaccharide receptor complex
    • membrane raft
    • mitochondrial crista
    • mitochondrion
    • rough endoplasmic reticulum
    • secretory granule
    • zymogen granule

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Summary text based on GO annotations supported by structural data

• Hspd1 encodes a protein or proteins that contain the following InterPro domains: Chaperone, tailless complex polypeptide 1, Chaperonin Cpn60, Chaperonin Cpn60, conserved site, Chaperonin Cpn60/TCP-1, indicating that the gene product:
  • participates in the following biological processes:
    • cellular protein metabolic process
    • protein folding
  • performs the following molecular functions:
    • ATP binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Hspd1 indicates that it:
  • performs the following molecular functions:
    • ATP binding
    • nucleotide binding

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References

1. Asquith KL et al. (2004) Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition. J Cell Sci, 117:3645-57. (PubMed:15252132)
2. Brudzynski K et al. (1995) A family of hsp60-related proteins in pancreatic beta cells of non-obese diabetic (NOD) mice. J Autoimmun, 8:859-74. (PubMed:8824711)
3. Brudzynski K et al. (1992) Immunocytochemical localization of heat-shock protein 60-related protein in beta-cell secretory granules and its altered distribution in non-obese diabetic mice. Diabetologia, 35:316-24. (PubMed:1516759)
4. Chang M et al. (2011) The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol, 12:1002-9. (PubMed:21874024)
5. Chen G et al. (1999) Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem, 274:7-10. (PubMed:9867803)
6. Chen W et al. (2006) Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur J Immunol, 36:1598-607. (PubMed:16708399)
7. Da Cruz S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J Biol Chem, 278:41566-71. (PubMed:12865426)
8. Danial NN et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature, 424:952-6. (PubMed:12931191)
9. Haigis MC et al. (2006) SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell, 126:941-54. (PubMed:16959573)
10. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
11. Osterloh A et al. (2007) Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide. J Biol Chem, 282:4669-80. (PubMed:17164250)
12. Osterloh A et al. (2004) Lipopolysaccharide-free heat shock protein 60 activates T cells. J Biol Chem, 279:47906-11. (PubMed:15371451)
13. Osterloh A et al. (2008) Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12. Int Immunol, 20:433-43. (PubMed:18256040)
14. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
15. Zhu Y et al. (2004) Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc Natl Acad Sci U S A, 101:7681-6. (PubMed:15136728)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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