Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hsf1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Hsf1
  • participates in the following biological processes:
    • protein phosphorylation ^[5]
  • performs the following molecular functions:
    • chromatin binding ^[6]
    • DNA binding ^[2]
    • sequence-specific DNA binding ^[5]
  • is located in the following cellular components:
    • cytoplasm ^{[2, 3]}
    • nucleus ^[2]
    • pronucleus ^[3]
• Researchers have inferred, based on physical interactions, that the gene product of Hsf1
  • is located in the following cellular components:
    • protein complex ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Hsf1
  • participates in the following biological processes:
    • embryonic placenta development ^[8]
    • embryonic process involved in female pregnancy ^[8]
    • female meiosis ^[6]
    • in utero embryonic development ^[8]
    • negative regulation of tumor necrosis factor production ^[8]
    • positive regulation of multicellular organism growth ^[8]
    • regulation of spindle checkpoint ^[6]
    • response to heat ^[8]
    • response to lipopolysaccharide ^[8]
• Researchers have inferred, based on genetic interactions, that the gene product of Hsf1
  • participates in the following biological processes:
    • negative regulation of cell proliferation based on interactions with Hsf4 ^[4]
    • spermatogenesis based on interactions with Hsf2 ^[7]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Hsf1:
  • participates in the following biological processes:
    • defense response
    • positive regulation of transcription from RNA polymerase II promoter
  • performs the following molecular functions:
    • RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
  • is located in the following cellular components:
    • cytoplasm
    • nucleus

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Summary text based on GO annotations supported by structural data

• Hsf1 encodes a protein or proteins that contain the following InterPro domains: Heat shock factor (HSF)-type, DNA-binding, Vertebrate heat shock transcription factor, Winged helix-turn-helix transcription repressor DNA-binding, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • sequence-specific DNA binding transcription factor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Hsf1 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • response to stress
    • transcription, DNA-dependent

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References

1. Boyault C et al. (2007) HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev, 21:2172-81. (PubMed:17785525)
2. Eriksson M et al. (2000) Heat shock factor 2 is activated during mouse heart development. Int J Dev Biol, 44:471-7. (PubMed:11032181)
3. Fiorenza MT et al. (2004) Early transcriptional activation of the hsp70.1 gene by osmotic stress in one-cell embryos of the mouse. Biol Reprod, 70:1606-13. (PubMed:14766729)
4. Fujimoto M et al. (2004) HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J, 23:4297-306. (PubMed:15483628)
5. Fujimoto M et al. (2008) Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses. J Biol Chem, 283:29961-70. (PubMed:18755693)
6. Le Masson F et al. (2011) Identification of Heat Shock Factor 1 Molecular and Cellular Targets during Embryonic and Adult Female Meiosis. Mol Cell Biol, 31:3410-23. (PubMed:21690297)
7. Wang G et al. (2004) Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility. Genesis, 38:66-80. (PubMed:14994269)
8. Xiao X et al. (1999) HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J, 18:5943-52. (PubMed:10545106)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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