Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of H2-M3. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 25, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of H2-M3
  • participates in the following biological processes:
    • antigen processing and presentation of endogenous peptide antigen via MHC class Ib ^[3]
    • antigen processing and presentation of exogenous peptide antigen via MHC class Ib ^[1]
    • antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent ^[2]
    • defense response to bacterium ^{[1, 4]}
    • positive regulation of T cell mediated cytotoxicity ^{[1, 2, 3, 4]}
    • response to molecule of bacterial origin ^[2]
  • performs the following molecular functions:
    • peptide antigen binding ^{[1, 3, 4]}
  • is located in the following cellular components:
    • external side of plasma membrane ^{[3, 4]}
    • MHC class Ib protein complex ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of H2-M3
  • participates in the following biological processes:
    • alpha-beta T cell activation involved in immune response ^[4]
    • defense response to bacterium ^[4]
    • positive regulation of interferon-gamma production ^[4]
    • positive regulation of natural killer cell mediated cytotoxicity ^[4]
    • positive regulation of nitric oxide biosynthetic process ^[4]
    • positive regulation of T cell mediated cytotoxicity ^[4]
  • performs the following molecular functions:
    • peptide antigen binding ^[4]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of H2-M3:
  • participates in the following biological processes:
    • immune response-inhibiting cell surface receptor signaling pathway
    • negative regulation of dendritic cell differentiation
    • negative regulation of T cell proliferation
    • positive regulation of interleukin-12 production
    • positive regulation of regulatory T cell differentiation
    • positive regulation of T cell tolerance induction
  • performs the following molecular functions:
    • receptor binding

---

References

1. D'Orazio SE et al. (2006) H2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenes. J Exp Med, 203:383-91. (PubMed:16461341)
2. Ugrinovic S et al. (2005) H2-M3 major histocompatibility complex class Ib-restricted CD8 T cells induced by Salmonella enterica serovar Typhimurium infection recognize proteins released by Salmonella serovar Typhimurium. Infect Immun, 73:8002-8. (PubMed:16299293)
3. Wang CR et al. (1993) HMT, encoded by H-2M3, is a neoclassical major histocompatibility class I antigen. Proc Natl Acad Sci U S A, 90:2784-8. (PubMed:8464890)
4. Xu H et al. (2006) Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense. J Exp Med, 203:449-59. (PubMed:16476767)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---