Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Grik5. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 15, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Grik5
  • is located in the following cellular components:
    • membrane ^[2]
    • postsynaptic membrane ^[2]
    • presynaptic membrane ^[2]
• The gene product of Grik5 has been shown to bind to the gene products of Gnaq. ^[4] Researchers have inferred, based on physical interactions, that the gene product of Grik5
  • performs the following molecular functions:
  • is located in the following cellular components:
    • kainate selective glutamate receptor complex ^{[2, 3]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Grik5
  • participates in the following biological processes:
    • regulation of excitatory postsynaptic membrane potential ^[1]
    • regulation of synaptic vesicle fusion to presynaptic membrane ^[1]
    • synaptic transmission, glutamatergic ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Grik5
  • participates in the following biological processes:
    • ionotropic glutamate receptor signaling pathway based on interactions with Grik2 ^[5]
    • regulation of membrane potential based on interactions with Grik2 ^[5]
  • performs the following molecular functions:
    • kainate selective glutamate receptor activity based on interactions with Grik2 ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Grik5:
  • participates in the following biological processes:
    • establishment of localization in cell
    • ionotropic glutamate receptor signaling pathway
    • positive regulation of neuron apoptotic process
    • protein retention in ER lumen
    • receptor clustering
    • signal transduction
    • synaptic transmission
  • performs the following molecular functions:
    • glutamate receptor activity
    • identical protein binding
    • kainate selective glutamate receptor activity
    • PDZ domain binding
    • SH3 domain binding
  • is located in the following cellular components:
    • axon
    • dendrite
    • ionotropic glutamate receptor complex
    • neuron projection
    • neuronal cell body
    • perikaryon
    • postsynaptic density
    • terminal button

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Summary text based on GO annotations supported by structural data

• Grik5 encodes a protein or proteins that contain the following InterPro domains: Extracellular ligand-binding receptor, Glutamate receptor, L-glutamate/glycine-binding, Ionotropic glutamate receptor, NMDA receptor, indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
  • performs the following molecular functions:
    • extracellular-glutamate-gated ion channel activity
    • ion channel activity
    • ionotropic glutamate receptor activity
    • receptor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Grik5 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • ion channel activity
  • is located in the following cellular components:
    • cell junction
    • integral to membrane
    • plasma membrane
    • synapse

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References

1. Contractor A et al. (2003) Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice. J Neurosci, 23:422-9. (PubMed:12533602)
2. Darstein M et al. (2003) Distribution of kainate receptor subunits at hippocampal mossy fiber synapses. J Neurosci, 23:8013-9. (PubMed:12954862)
3. Kayadjanian N et al. (2007) Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17. Mol Cell Neurosci, 34:219-30. (PubMed:17174564)
4. Ruiz A et al. (2005) Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses. J Neurosci, 25:11710-8. (PubMed:16354929)
5. Sakimura K et al. (1992) Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron, 8:267-74. (PubMed:1310861)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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