Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ggt1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ggt1
  • is located in the following cellular components:
    • membrane-bounded vesicle ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ggt1
  • participates in the following biological processes:
    • cysteine biosynthetic process ^[2]
    • glutathione biosynthetic process ^[2]
    • regulation of immune system process ^[2]
    • regulation of inflammatory response ^[2]
    • spermatogenesis ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ggt1:
  • participates in the following biological processes:
    • glutamate metabolic process
    • glutathione catabolic process
    • leukotriene biosynthetic process
    • peptide modification
    • proteolysis
    • zymogen activation
  • performs the following molecular functions:
    • gamma-glutamyltransferase activity
    • glutathione hydrolase activity
  • is located in the following cellular components:
    • extracellular space
    • extracellular vesicular exosome
    • plasma membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ggt1 indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
    • peptidase activity
    • transferase activity
    • transferase activity, transferring acyl groups
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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References

1. Harding CO et al. (1997) Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility. J Biol Chem, 272:12560-7. (PubMed:9139708)
2. Pardo A et al. (2003) Bleomycin-induced pulmonary fibrosis is attenuated in gamma-glutamyl transpeptidase-deficient mice. Am J Respir Crit Care Med, 167:925-32. (PubMed:12468440)
3. Sizova D et al. (2013) Renalase regulates renal dopamine and phosphate metabolism. Am J Physiol Renal Physiol, 305:F839-44. (PubMed:23863468)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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