Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ggt1. (This text reflects annotations as of Thursday, January 16, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The enzyme encoded by this gene catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized and some of which may represent pseudogenes. This gene is classified as type I gamma-glutamyltransferase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ggt1
  • is located in the following cellular components:
    • membrane-bounded vesicle ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ggt1
  • participates in the following biological processes:
    • cysteine biosynthetic process ^[2]
    • glutathione biosynthetic process ^[2]
    • regulation of immune system process ^[2]
    • regulation of inflammatory response ^[2]
    • spermatogenesis ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ggt1:
  • participates in the following biological processes:
    • glutamate metabolic process
    • glutathione catabolic process
    • leukotriene biosynthetic process
  • performs the following molecular functions:
    • gamma-glutamyltransferase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ggt1 indicates that it:
  • participates in the following biological processes:
    • proteolysis
  • performs the following molecular functions:
    • hydrolase activity
    • peptidase activity
    • transferase activity
    • transferase activity, transferring acyl groups
  • is located in the following cellular components:
    • integral component of membrane
    • membrane
• Ggt1 has been associated with the Enzyme Commission numbers: 2.3.2.2, 3.4.19.13, 3.4.19.14, which implies that the gene product:
  • performs the following molecular functions:
    • glutathione hydrolase activity

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References

1. Harding CO et al. (1997) Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility. J Biol Chem, 272:12560-7. (PubMed:9139708)
2. Pardo A et al. (2003) Bleomycin-induced pulmonary fibrosis is attenuated in gamma-glutamyl transpeptidase-deficient mice. Am J Respir Crit Care Med, 167:925-32. (PubMed:12468440)
3. Sizova D et al. (2013) Renalase regulates renal dopamine and phosphate metabolism. Am J Physiol Renal Physiol, 305:F839-44. (PubMed:23863468)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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