Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gabrg2. (This text reflects annotations as of Wednesday, August 14, 2013.)

---

Summary from NCBI RefSeq

This gene encodes a gamma-aminobutyric acid (GABA)-A receptor subunit, which is a member of the ligand-gated ion channel family. GABA is the major inhibitory neurotransmitter in the adult central nervous system, and conversely exhibits an excitatory function during development. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. This gene encodes one of three gamma subunits in mammals, which contain the binding site for benzodiazepine drugs. Several mutations in this gene are associated with epileptic seizures, and genetic knockdown is associated with anxiety behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Gabrg2
  • participates in the following biological processes:
    • gamma-aminobutyric acid signaling pathway ^[3]
    • synaptic transmission ^[3]
  • performs the following molecular functions:
    • GABA-A receptor activity ^[3]
  • is located in the following cellular components:
    • axon ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Gabrg2
  • participates in the following biological processes:
    • adult behavior ^[1]
    • post-embryonic development ^[1]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gabrg2:
  • participates in the following biological processes:
    • synaptic transmission, GABAergic
  • performs the following molecular functions:
    • chloride channel activity
    • GABA-A receptor activity
  • is located in the following cellular components:
    • cytoplasm
    • dendrite membrane
    • inhibitory synapse

---

Summary text based on GO annotations supported by structural data

• Gabrg2 encodes a protein or proteins that contain the following InterPro domains: Gamma-aminobutyric acid A receptor, Gamma-aminobutyric-acid A receptor, gamma 2 subunit, Gamma-aminobutyric-acid A receptor, gamma subunit, Neurotransmitter-gated ion-channel, Neurotransmitter-gated ion-channel ligand-binding, Neurotransmitter-gated ion-channel transmembrane domain, Neurotransmitter-gated ion-channel, conserved site, indicating that the gene product:
  • participates in the following biological processes:
    • chloride transport
    • ion transport
    • transport
  • performs the following molecular functions:
    • extracellular ligand-gated ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gabrg2 indicates that it:
  • participates in the following biological processes:
    • chloride transport
    • ion transport
    • transport
  • is located in the following cellular components:
    • cell junction
    • chloride channel complex
    • integral to membrane
    • membrane
    • plasma membrane
    • postsynaptic membrane
    • synapse

---

References

1. Chandra D et al. (2005) GABAA receptor gamma2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines. BMC Neurosci, 6:30. (PubMed:15850489)
2. Fritschy JM et al. (1998) Independent assembly and subcellular targeting of GABA(A)-receptor subtypes demonstrated in mouse hippocampal and olfactory neurons in vivo. Neurosci Lett, 249:99-102. (PubMed:9682826)
3. Wang J et al. (2003) Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses. J Neurosci, 23:826-36. (PubMed:12574411)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---