Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables GABA-A receptor activity; chloride channel activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Contributes to GABA-gated chloride ion channel activity. Involved in cellular response to histamine; chloride transmembrane transport; and inhibitory synapse assembly. Acts upstream of or within several processes, including chemical postsynaptic transmission; gamma-aminobutyric acid signaling pathway; and regulation of postsynaptic membrane potential. Located in axon and plasma membrane. Part of GABA-A receptor complex. Is active in GABA-ergic synapse. Is expressed in central nervous system; eye; palatal shelf; and peripheral nervous system ganglion. Used to study generalized epilepsy with febrile seizures plus. Human ortholog(s) of this gene implicated in childhood absence epilepsy; developmental and epileptic encephalopathy 74; and familial febrile seizures 8. Orthologous to human GABRG2 (gamma-aminobutyric acid type A receptor subunit gamma2).