Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables glucose-6-phosphatase activity and phosphotransferase activity, alcohol group as acceptor. Involved in gluconeogenesis. Acts upstream of or within several processes, including cholesterol homeostasis; glucose-6-phosphate transport; and glycogen catabolic process. Is active in endoplasmic reticulum. Is expressed in embryo; liver; metanephros; and small intestine. Used to study glycogen storage disease Ia. Human ortholog(s) of this gene implicated in glycogen storage disease Ia; hepatocellular carcinoma; and type 2 diabetes mellitus. Orthologous to human G6PC1 (glucose-6-phosphatase catalytic subunit 1).