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Gene Ontology Classifications
Symbol
Name
ID
Fcgr2b
Fc receptor, IgG, low affinity IIb
MGI:95499

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fcgr2b. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text for additional MGI annotations
References
  1. Bolland S et al. (2002) Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. J Exp Med, 195:1167-74. (PubMed:11994421)
  2. Gavin AL et al. (1998) Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity. J Immunol, 160:20-3. (PubMed:9551950)
  3. Gjertsson I et al. (2002) The impact of Fcgamma receptors on Staphylococcus aureus infection. Microb Pathog, 33:145-52. (PubMed:12385742)
  4. Hazenbos WL et al. (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity, 5:181-8. (PubMed:8769481)
  5. Kumagai H et al. (2003) Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Biochem Biophys Res Commun, 307:719-29. (PubMed:12893283)
  6. Nishimura H et al. (2006) Involvement of a tissue-specific autoantibody in skin disorders of murine systemic lupus erythematosus and autoinflammatory diseases. Proc Natl Acad Sci U S A, 103:3292-7. (PubMed:16492738)
  7. Takai T et al. (1996) Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature, 379:346-9. (PubMed:8552190)
  8. Wernersson S et al. (1999) IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice. J Immunol, 163:618-22. (PubMed:10395649)
  9. Yada A et al. (2003) Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake. Cell Immunol, 225:21-32. (PubMed:14643301)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory