Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Epo. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Epo
  • participates in the following biological processes:
    • apoptotic process ^[5]
    • embryo implantation ^[5]
    • erythrocyte differentiation ^[3]
    • hemoglobin biosynthetic process ^[5]
    • negative regulation of apoptotic process ^[2]
    • negative regulation of myeloid cell apoptotic process ^[1]
    • peptidyl-serine phosphorylation ^[2]
    • positive regulation of protein kinase activity ^[2]
    • regulation of transcription from RNA polymerase II promoter ^[5]
    • response to hypoxia ^[4]
  • performs the following molecular functions:
    • protein kinase activator activity ^[2]
  • is located in the following cellular components:
    • extracellular space ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Epo:
  • participates in the following biological processes:
    • cellular hyperosmotic response
    • negative regulation of apoptotic process
    • negative regulation of ion transmembrane transporter activity
    • negative regulation of sodium ion transport
    • positive regulation of cell proliferation
    • positive regulation of DNA replication
    • positive regulation of neuron differentiation
    • positive regulation of Ras protein signal transduction
    • positive regulation of transcription, DNA-dependent
    • positive regulation of tyrosine phosphorylation of Stat5 protein
  • performs the following molecular functions:
    • eukaryotic cell surface binding
  • is located in the following cellular components:
    • extracellular region
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Epo encodes a protein or proteins that contain the following InterPro domains: Erythropoietin, Erythropoietin/thrombopoeitin, Erythropoietin/thrombopoeitin, conserved site, Four-helical cytokine, core, Four-helical cytokine-like, core, indicating that the gene product:
  • performs the following molecular functions:
    • hormone activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Epo indicates that it:
  • participates in the following biological processes:
    • erythrocyte maturation
  • performs the following molecular functions:
    • hormone activity

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References

1. Cheng J et al. (2007) SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell, 131:584-95. (PubMed:17981124)
2. Deng H et al. (2011) Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells. Int J Biochem Cell Biol, 43:409-15. (PubMed:21095239)
3. Lenox LE et al. (2005) BMP4 and Madh5 regulate the erythroid response to acute anemia. Blood, 105:2741-8. (PubMed:15591122)
4. Suliman HB et al. (2004) Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. Blood, 104:43-50. (PubMed:15016652)
5. Yasuda Y et al. (2007) Erythropoietin contributes to implantation: ectopic hemoglobin synthesis in decidual cells of mice. Congenit Anom (Kyoto), 47:22-33. (PubMed:17300687)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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