Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Adipor2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Adipor2
  • performs the following molecular functions:
    • identical protein binding ^[1]
    • receptor activity ^[1]
• The gene product of Adipor2 has been shown to bind to the gene products of Adipoq. ^[1] Researchers have inferred, based on physical interactions, that the gene product of Adipor2
  • performs the following molecular functions:
    • protein heterodimerization activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Adipor2:
  • participates in the following biological processes:
    • fatty acid oxidation
    • hormone-mediated signaling pathway
    • negative regulation of cell growth
    • positive regulation of glucose import
  • performs the following molecular functions:
    • hormone binding

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Summary text based on GO annotations supported by structural data

• Adipor2 encodes a protein or proteins that contain the following InterPro domains: Hly-III-related, indicating that the gene product:
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Adipor2 indicates that it:
  • participates in the following biological processes:
    • fatty acid metabolic process
    • lipid metabolic process
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Yamauchi T et al. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature, 423:762-9. (PubMed:12802337)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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