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Gene Ontology Classifications
Symbol
Name
ID
Frzb
frizzled-related protein
MGI:892032

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Frzb. (This text reflects annotations as of Thursday, January 16, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. Alfieri CM et al. (2010) Wnt signaling in heart valve development and osteogenic gene induction. Dev Biol, 338:127-35. (PubMed:19961844)
  2. Bi Y et al. (2009) Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells. J Cell Biochem, 108:295-303. (PubMed:19562671)
  3. Liu W et al. (2008) Coordinated molecular control of otic capsule differentiation: functional role of Wnt5a signaling and opposition by sfrp3 activity. Growth Factors, 26:343-54. (PubMed:18991062)
  4. Mayr T et al. (1997) Fritz: a secreted frizzled-related protein that inhibits Wnt activity. Mech Dev, 63:109-25. (PubMed:9178261)
  5. Qian D et al. (2007) Wnt5a functions in planar cell polarity regulation in mice. Dev Biol, 306:121-33. (PubMed:17433286)
  6. Rattner A et al. (1997) A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A, 94:2859-63. (PubMed:9096311)
  7. Wawrzak D et al. (2007) Wnt3a binds to several sFRPs in the nanomolar range. Biochem Biophys Res Commun, 357:1119-23. (PubMed:17462603)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory