Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Frzb. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Frzb
  • participates in the following biological processes:
    • inner ear morphogenesis ^[4]
    • negative regulation of cell development ^[2]
    • negative regulation of hepatocyte differentiation ^[2]
    • negative regulation of Wnt signaling pathway ^[5]
  • performs the following molecular functions:
    • Wnt-protein binding ^[5]
• The gene product of Frzb has been shown to bind to the gene products of Myoc. ^{[3, 7]} Researchers have inferred, based on physical interactions, that the gene product of Frzb
  • performs the following molecular functions:
    • Wnt-protein binding ^[8]
• Researchers have inferred, based on genetic interactions, that the gene product of Frzb
  • participates in the following biological processes:
    • cochlea morphogenesis based on interactions with Wnt5a ^[6]
    • convergent extension involved in organogenesis based on interactions with Wnt5a ^[6]
    • inner ear morphogenesis based on interactions with Wnt5a ^[4]
    • negative regulation of canonical Wnt signaling pathway based on interactions with Wnt3a ^[1]
    • negative regulation of cartilage development based on interactions with Wnt5a ^[4]
    • negative regulation of Wnt signaling pathway based on interactions with Wnt5a ^[6]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Frzb:
  • participates in the following biological processes:
    • brain development
    • gonad development
    • mammary gland involution
    • negative regulation of canonical Wnt signaling pathway
    • negative regulation of cell growth
    • negative regulation of cell proliferation
    • negative regulation of Wnt signaling pathway
    • positive regulation of apoptotic process
    • positive regulation of fat cell differentiation
    • regulation of transcription from RNA polymerase II promoter
    • signal transduction
    • vasculature development
  • performs the following molecular functions:
    • PDZ domain binding
    • Wnt-activated receptor activity
  • is located in the following cellular components:
    • cytoplasm
    • extracellular space

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Frzb indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • Wnt signaling pathway

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References

1. Alfieri CM et al. (2010) Wnt signaling in heart valve development and osteogenic gene induction. Dev Biol, 338:127-35. (PubMed:19961844)
2. Bi Y et al. (2009) Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells. J Cell Biochem, 108:295-303. (PubMed:19562671)
3. Kwon HS et al. (2009) Myocilin is a modulator of Wnt signaling. Mol Cell Biol, 29:2139-54. (PubMed:19188438)
4. Liu W et al. (2008) Coordinated molecular control of otic capsule differentiation: functional role of Wnt5a signaling and opposition by sfrp3 activity. Growth Factors, 26:343-54. (PubMed:18991062)
5. Mayr T et al. (1997) Fritz: a secreted frizzled-related protein that inhibits Wnt activity. Mech Dev, 63:109-25. (PubMed:9178261)
6. Qian D et al. (2007) Wnt5a functions in planar cell polarity regulation in mice. Dev Biol, 306:121-33. (PubMed:17433286)
7. Rattner A et al. (1997) A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A, 94:2859-63. (PubMed:9096311)
8. Wawrzak D et al. (2007) Wnt3a binds to several sFRPs in the nanomolar range. Biochem Biophys Res Commun, 357:1119-23. (PubMed:17462603)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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