Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc22a6. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc22a6
  • participates in the following biological processes:
    • anion transport ^[2]
    • ion transmembrane transport ^[2]
    • organic anion transport ^[2]
  • performs the following molecular functions:
    • organic anion transmembrane transporter activity ^[2]
  • is located in the following cellular components:
    • integral to plasma membrane ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc22a6
  • participates in the following biological processes:
    • organic anion transport ^[1]
    • renal tubular secretion ^[1]
  • performs the following molecular functions:
    • organic anion transmembrane transporter activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc22a6:
  • participates in the following biological processes:
    • alpha-ketoglutarate transport
    • ion transmembrane transport
    • organic anion transport
    • renal tubular secretion
    • sodium-independent organic anion transport
  • performs the following molecular functions:
    • inorganic anion exchanger activity
    • organic anion transmembrane transporter activity
    • sodium-independent organic anion transmembrane transporter activity
  • is located in the following cellular components:
    • basolateral plasma membrane
    • caveola
    • integral to plasma membrane
    • plasma membrane
    • protein complex

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Summary text based on GO annotations supported by structural data

• Slc22a6 encodes a protein or proteins that contain the following InterPro domains: General substrate transporter, Major facilitator superfamily domain, Major facilitator superfamily domain, general substrate transporter, Organic cation transport protein, indicating that the gene product:
  • participates in the following biological processes:
    • transmembrane transport
  • performs the following molecular functions:
    • ion transmembrane transporter activity
    • transmembrane transporter activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc22a6 indicates that it:
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Kittayaruksakul S et al. (2012) Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. Am J Physiol Renal Physiol, 302:F552-60. (PubMed:22169006)
2. Pavlova A et al. (2000) Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct. Am J Physiol Renal Physiol, 278:F635-43. (PubMed:10751225)
3. Tanaka K et al. (2004) Role of glycosylation in the organic anion transporter OAT1. J Biol Chem, 279:14961-6. (PubMed:14749323)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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