Automated description from the Alliance of Genome Resources (Release 4.0)
Enables steroid 11-beta-monooxygenase activity. Involved in several processes, including C21-steroid hormone biosynthetic process; cholesterol metabolic process; and glucocorticoid metabolic process. Acts upstream of or within several processes, including aldosterone biosynthetic process; drinking behavior; and regulation of systemic arterial blood pressure by hormone. Located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in adrenal gland and gland. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to several human genes including CYP11B2 (cytochrome P450 family 11 subfamily B member 2).