Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits corticosterone 18-monooxygenase activity. Involved in glucocorticoid biosynthetic process. Localizes to mitochondrion. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia; diabetes mellitus (multiple); dilated cardiomyopathy 1H; hypertension (multiple); and primary hyperaldosteronism (multiple). Is expressed in adrenal gland; gland; lung; and testis. Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (cytochrome P450 family 11 subfamily B member 2).