Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cyp11b1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 15, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cyp11b1
  • participates in the following biological processes:
    • glucocorticoid biosynthetic process ^{[1, 4]}
    • oxidation-reduction process ^{[1, 4]}
  • performs the following molecular functions:
    • corticosterone 18-monooxygenase activity ^{[1, 4]}
  • is located in the following cellular components:
    • mitochondrion ^{[2, 3]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cyp11b1
  • participates in the following biological processes:
    • glucocorticoid biosynthetic process ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cyp11b1:
  • participates in the following biological processes:
    • aldosterone biosynthetic process
    • C21-steroid hormone biosynthetic process
    • cortisol biosynthetic process
    • glucocorticoid biosynthetic process
    • oxidation-reduction process
    • regulation of blood pressure
    • steroid biosynthetic process
  • performs the following molecular functions:
    • steroid 11-beta-monooxygenase activity
    • steroid binding
  • is located in the following cellular components:
    • integral to endoplasmic reticulum membrane
    • mitochondrion

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cyp11b1 indicates that it:
  • performs the following molecular functions:
    • metal ion binding
    • monooxygenase activity
    • oxidoreductase activity

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References

1. Domalik LJ et al. (1991) Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids. Mol Endocrinol, 5:1853-61. (PubMed:1686470)
2. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
3. Pazirandeh A et al. (1999) Paracrine glucocorticoid activity produced by mouse thymic epithelial cells. FASEB J, 13:893-901. (PubMed:10224232)
4. Veronneau S et al. (1996) The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity. J Steroid Biochem Mol Biol, 57:125-39. (PubMed:8645611)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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