Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables several functions, including calcium ion binding activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including cell junction assembly; cell-cell adhesion mediated by cadherin; and neuronal stem cell population maintenance. Acts upstream of or within several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; nervous system development; and regulation of signal transduction. Located in several cellular components, including apicolateral plasma membrane; basolateral plasma membrane; and fascia adherens. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; intervertebral disc; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in agenesis of corpus callosum, cardiac, ocular, and genital syndrome; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 14. Orthologous to human CDH2 (cadherin 2).