Automated description from the Alliance of Genome Resources (Release 4.0)
Exhibits calcium ion binding activity; carbohydrate binding activity; and mRNA binding activity. Involved in several processes, including peptide antigen assembly with MHC class I protein complex; positive regulation of NIK/NF-kappaB signaling; and protein stabilization. Localizes to endoplasmic reticulum; external side of plasma membrane; and extracellular space. Is expressed in several structures, including central nervous system; extraembryonic component; gut; placenta; and spleen. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; sideroblastic anemia; and thrombocytosis. Orthologous to human CALR (calreticulin).