Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Glb1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes beta-galactosidase-1, a lysosomal enzyme that hydrolyzes the terminal beta-galactose from ganglioside substrates and other glycoconjugates. Defects in this gene are the cause of GM1-gangliosidosis and Morquio B syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Glb1
  • participates in the following biological processes:
    • metabolic process ^{[1, 2, 3]}
  • performs the following molecular functions:
    • beta-galactosidase activity ^{[1, 2, 3]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Glb1:
  • participates in the following biological processes:
    • galactose catabolic process
  • performs the following molecular functions:
    • beta-galactosidase activity
    • galactoside binding
  • is located in the following cellular components:
    • lysosome

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Summary text based on GO annotations supported by structural data

• Glb1 encodes a protein or proteins that contain the following InterPro domains: Beta-galactosidase 1-like, Galactose-binding domain-like, Glycoside hydrolase, catalytic domain, Glycoside hydrolase, family 35, Glycoside hydrolase, family 35, conserved site, Glycoside hydrolase, superfamily, indicating that the gene product:
  • participates in the following biological processes:
    • carbohydrate metabolic process
  • performs the following molecular functions:
    • catalytic activity
    • cation binding
    • hydrolase activity, hydrolyzing O-glycosyl compounds

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Glb1 indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
    • hydrolase activity, acting on glycosyl bonds

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References

1. Felton J et al. (1974) A locus determining beta-galactosidase activity in the mouse. J Biol Chem, 249:3267-72. (PubMed:4830244)
2. Gibb S et al. (1981) Reduced pigmentation (rp), a new coat colour gene with effects on kidney lysosomal glycosidases in the mouse. Genet Res, 37:95-103. (PubMed:7203014)
3. Yasue M et al. (1991) Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids. Cytogenet Cell Genet, 57:142-8. (PubMed:1914521)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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