Automated description from the Alliance of Genome Resources
Predicted to have arachidonate 5-lipoxygenase activity and iron ion binding activity. Involved in leukotriene biosynthetic process and leukotriene production involved in inflammatory response. Localizes to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in arteriosclerosis; asthma; pancreatic cancer; pulmonary hypertension; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).