Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Aspa. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

This gene encodes an enzyme that deacteylates N-acetyl-L-aspartic acid (NAA) in the brain to yield acetate and L-aspartate. In humans, alterations in neuronal NAA concentration are associated with many neurodegenerative diseases (decrease associated with epilepsy, multiple sclerosis, myotrophic lateral sclerosis, and Alzheimer's disease; increase associated with Canavan disease). In mouse, mutations in this gene, which cause accumulation of NAA, result in demyelination and spongy degeneration in the CNS and serve as a pathophysiological model for Canavan disease. [provided by RefSeq, Dec 2012]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Aspa:
  • participates in the following biological processes:
    • positive regulation of oligodendrocyte differentiation
  • is located in the following cellular components:
    • cytoplasm
    • nucleus

---

Summary text based on GO annotations supported by structural data

• Aspa encodes a protein or proteins that contain the following InterPro domains: Aspartoacylase, Succinylglutamate desuccinylase/aspartoacylase, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    • hydrolase activity, acting on ester bonds

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Aspa indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding
• Aspa has been associated with the Enzyme Commission numbers: 3.5.1.15, which implies that the gene product:
  • performs the following molecular functions:
    • aspartoacylase activity

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---