Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Actc1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 11, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Actc1
  • is located in the following cellular components:
    • I band ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Actc1
  • participates in the following biological processes:
    • actomyosin structure organization ^[1]
    • apoptotic process ^[1]
    • cardiac muscle tissue morphogenesis ^[1]
    • cardiac myofibril assembly ^[3]
    • skeletal muscle thin filament assembly ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Actc1:
  • participates in the following biological processes:
    • actin filament-based movement
    • actin-myosin filament sliding
    • ATP catabolic process
    • cardiac muscle contraction
    • heart contraction
  • performs the following molecular functions:
    • ATP binding
    • ATPase activity
    • myosin binding
  • is located in the following cellular components:
    • actin filament
    • actomyosin, actin part
    • cytoplasm
    • extracellular vesicular exosome
    • sarcomere

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Actc1 indicates that it:
  • performs the following molecular functions:
    • nucleotide binding
  • is located in the following cellular components:
    • cytoskeleton

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References

1. Abdelwahid E et al. (2004) Cellular disorganization and extensive apoptosis in the developing heart of mice that lack cardiac muscle alpha-actin: apparent cause of perinatal death. Pediatr Res, 55:197-204. (PubMed:14605248)
2. Bennett PM et al. (2006) The transitional junction: a new functional subcellular domain at the intercalated disc. Mol Biol Cell, 17:2091-100. (PubMed:16481394)
3. Kumar A et al. (1997) Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin. Proc Natl Acad Sci U S A, 94:4406-11. (PubMed:9114002)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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