Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Acp2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Mutations in this gene or in the related alpha subunit gene cause acid phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Acp2
  • participates in the following biological processes:
    • dephosphorylation ^{[1, 5, 7]}
  • performs the following molecular functions:
    • acid phosphatase activity ^{[1, 5, 7]}
  • is located in the following cellular components:
    • lysosome ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Acp2
  • participates in the following biological processes:
    • dephosphorylation ^{[2, 4, 6]}
    • lysosome organization ^{[3, 4]}
    • skeletal system development ^[4]
  • performs the following molecular functions:
    • acid phosphatase activity ^{[2, 4, 6]}
  • is located in the following cellular components:
    • lysosome ^[6]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Acp2:
  • participates in the following biological processes:
    • autophagic cell death
    • response to organic substance
  • performs the following molecular functions:
    • acid phosphatase activity
    • phosphoprotein phosphatase activity
    • phosphotyrosine binding
  • is located in the following cellular components:
    • cytoplasmic vesicle
    • lysosome
    • neuron projection

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Acp2 indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Bune AJ et al. (2001) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus. Immunology, 102:103-13. (PubMed:11168643)
2. Mannan AU et al. (2004) Mutation in the gene encoding lysosomal acid phosphatase (Acp2) causes cerebellum and skin malformation in mouse. Neurogenetics, 5:229-38. (PubMed:15503243)
3. Muraoka-Cook RS et al. (2004) Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors. Cancer Res, 64:9002-11. (PubMed:15604265)
4. Saftig P et al. (1997) Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system. J Biol Chem, 272:18628-35. (PubMed:9228031)
5. Stallings RL et al. (1981) Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7. Somatic Cell Genet, 7:683-98. (PubMed:7323947)
6. Suter A et al. (2001) Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice. Development, 128:4899-910. (PubMed:11731469)
7. Yasue M et al. (1991) Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids. Cytogenet Cell Genet, 57:142-8. (PubMed:1914521)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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