Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Acat2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Acat2
  • is located in the following cellular components:
    • mitochondrion ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Acat2:
  • performs the following molecular functions:
    • acetyl-CoA C-acetyltransferase activity
  • is located in the following cellular components:
    • cytoplasm
    • mitochondrion
    • nucleolus
    • nucleus

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Summary text based on GO annotations supported by structural data

• Acat2 encodes a protein or proteins that contain the following InterPro domains: Thiolase, Thiolase, active site, Thiolase, C-terminal, Thiolase, conserved site, Thiolase, N-terminal, Thiolase-like, Thiolase-like, subgroup, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • catalytic activity
    • transferase activity, transferring acyl groups other than amino-acyl groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Acat2 indicates that it:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • transferase activity
    • transferase activity, transferring acyl groups

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References

1. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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