Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kcnj13. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 2, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the inwardly rectifying potassium channel family of proteins. Members of this family form ion channel pores that allow potassium ions to pass into a cell. The encoded protein belongs to a subfamily of low signal channel conductance proteins that have a low dependence on potassium concentration. Mutations in this gene are associated with snowflake vitreoretinal degeneration. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

---

Summary text based on GO annotations supported by structural data

• Kcnj13 encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin E-set, Potassium channel, inwardly rectifying, Kir, Potassium channel, inwardly rectifying, Kir, cytoplasmic, Potassium channel, inwardly rectifying, Kir7, indicating that the gene product:
  • participates in the following biological processes:
    • potassium ion transport
  • performs the following molecular functions:
    • inward rectifier potassium channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Kcnj13 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • potassium ion transport
    • regulation of ion transmembrane transport
    • transport
  • performs the following molecular functions:
    • ion channel activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---