Automated description from the Alliance of Genome Resources (Release 7.1.0)
Predicted to enable K63-linked deubiquitinase activity; metal-dependent deubiquitinase activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including DNA repair-dependent chromatin remodeling; mitotic G2 DNA damage checkpoint signaling; and positive regulation of NLRP3 inflammasome complex assembly. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Orthologous to human BRCC3 (BRCA1/BRCA2-containing complex subunit 3).