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Gene Ontology Classifications
Symbol
Name
ID
Syngap1
synaptic Ras GTPase activating protein 1 homolog (rat)
MGI:3039785

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Syngap1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. The encoded protein is phosphorylated by calmodulin-dependent protein kinase II and dephosphorylated by NMDA receptor activation. Defects in this gene are a cause of mental retardation autosomal dominant type 5 (MRD5). [provided by RefSeq, Dec 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Barnett MW et al. (2006) Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice. J Neurosci, 26:1355-65. (PubMed:16452659)
  2. Kim JH et al. (2003) The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity. J Neurosci, 23:1119-24. (PubMed:12598599)
  3. Knuesel I et al. (2005) A role for synGAP in regulating neuronal apoptosis. Eur J Neurosci, 21:611-21. (PubMed:15733080)
  4. Komiyama NH et al. (2002) SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci, 22:9721-32. (PubMed:12427827)
  5. Tomoda T et al. (2004) Role of Unc51.1 and its binding partners in CNS axon outgrowth. Genes Dev, 18:541-58. (PubMed:15014045)
  6. Turcotte K et al. (2005) A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice. J Exp Med, 201:881-90. (PubMed:15781580)
  7. Vazquez LE et al. (2004) SynGAP regulates spine formation. J Neurosci, 24:8862-72. (PubMed:15470153)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory