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Gene Ontology Classifications
Symbol
Name
ID
Syngap1
synaptic Ras GTPase activating protein 1 homolog (rat)
MGI:3039785

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Automated description from the Alliance of Genome Resources (Release 5.2.0)

Enables GTPase activator activity. Involved in maintenance of postsynaptic specialization structure. Acts upstream of or within several processes, including negative regulation of axonogenesis; regulation of long-term neuronal synaptic plasticity; and visual learning. Located in dendritic shaft; membrane; and postsynaptic density. Is active in glutamatergic synapse. Used to study schizophrenia. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 5. Orthologous to human SYNGAP1 (synaptic Ras GTPase activating protein 1).



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Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement

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Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory