Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bbs12. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 2, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is part of a complex that is involved in membrane trafficking. The encoded protein is a molecular chaperone that aids in protein folding upon ATP hydrolysis. This protein also plays a role in adipocyte differentiation. Defects in this gene are a cause of Bardet-Biedl syndrome type 12. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Bbs12:
  • participates in the following biological processes:
    • chaperone-mediated protein complex assembly

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Summary text based on GO annotations supported by structural data

• Bbs12 encodes a protein or proteins that contain the following InterPro domains: Chaperonin Cpn60/TCP-1, indicating that the gene product:
  • participates in the following biological processes:
    • cellular protein metabolic process
  • performs the following molecular functions:
    • ATP binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Bbs12 indicates that it:
  • performs the following molecular functions:
    • ATP binding
    • nucleotide binding
  • is located in the following cellular components:
    • cell projection
    • cilium
• Annotations directly to for the gene Bbs12 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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