Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protein-macromolecule adaptor activity. Involved in negative regulation of inflammatory response and negative regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within cellular response to cytokine stimulus; dendritic cell migration; and negative regulation of ERK1 and ERK2 cascade. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 2. Orthologous to human NLRP12 (NLR family pyrin domain containing 12).