Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Disc1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Disc1
  • participates in the following biological processes:
    • protein localization ^[2]
  • is located in the following cellular components:
    • centrosome ^[2]
• The gene product of Disc1 has been shown to bind to the gene products of Ccdc88a, Dixdc1, Gsk3b. ^{[2, 3, 4, 7]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Disc1
  • participates in the following biological processes:
    • canonical Wnt receptor signaling pathway ^{[2, 7]}
    • cell proliferation in forebrain ^[7]
    • cerebral cortex radially oriented cell migration ^[7]
    • mitochondrial calcium ion homeostasis ^[6]
    • neuron migration ^{[2, 5]}
    • positive regulation of neuroblast proliferation ^[4]
    • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process ^[6]
    • positive regulation of Wnt receptor signaling pathway ^{[4, 7]}
    • regulation of neuron projection development ^{[1, 3]}
    • regulation of synapse maturation ^[1]
    • TOR signaling cascade ^[3]
  • is located in the following cellular components:
    • intracellular ^[3]
    • mitochondrion ^[6]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Disc1:
  • participates in the following biological processes:
    • cilium assembly
    • microtubule cytoskeleton organization
    • nervous system development
    • neuron migration
    • positive regulation of axon extension
    • positive regulation of cell-matrix adhesion
    • positive regulation of neuroblast proliferation
    • positive regulation of neuron projection development
    • positive regulation of Wnt receptor signaling pathway
    • pyramidal neuron migration
    • regulation of dendritic spine development
    • regulation of neuron projection development
  • performs the following molecular functions:
    • kinesin binding
    • protein complex binding
  • is located in the following cellular components:
    • axon part
    • cell body
    • centrosome
    • dynein complex
    • endoplasmic reticulum
    • kinesin complex
    • mitochondrion
    • nucleus
    • perinuclear region of cytoplasm

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Disc1 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • Wnt receptor signaling pathway
  • is located in the following cellular components:
    • cell junction
    • cytoplasm
    • cytoskeleton
    • membrane
    • microtubule
    • plasma membrane
    • postsynaptic membrane
    • synapse

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References

1. Duan X et al. (2007) Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell, 130:1146-58. (PubMed:17825401)
2. Ishizuka K et al. (2011) DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature, 473:92-6. (PubMed:21471969)
3. Kim JY et al. (2009) DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron, 63:761-73. (PubMed:19778506)
4. Mao Y et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell, 136:1017-31. (PubMed:19303846)
5. Meyer KD et al. (2009) Disc1 regulates granule cell migration in the developing hippocampus. Hum Mol Genet, 18:3286-97. (PubMed:19502360)
6. Park YU et al. (2010) Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. Proc Natl Acad Sci U S A, 107:17785-90. (PubMed:20880836)
7. Singh KK et al. (2010) Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron, 67:33-48. (PubMed:20624590)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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