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Gene Ontology Classifications
disrupted in schizophrenia 1

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GO curators for mouse genes have assigned the following annotations to the gene product of Disc1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Duan X et al. (2007) Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell, 130:1146-58. (PubMed:17825401)
  2. Fukuda T et al. (2010) CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. J Biol Chem, 285:40554-61. (PubMed:20956536)
  3. Ishizuka K et al. (2011) DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature, 473:92-6. (PubMed:21471969)
  4. Kamiya A et al. (2008) Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. Arch Gen Psychiatry, 65:996-1006. (PubMed:18762586)
  5. Kim JY et al. (2009) DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron, 63:761-73. (PubMed:19778506)
  6. Mao Y et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell, 136:1017-31. (PubMed:19303846)
  7. Marley A et al. (2010) DISC1 regulates primary cilia that display specific dopamine receptors. PLoS One, 5:e10902. (PubMed:20531939)
  8. Meyer KD et al. (2009) Disc1 regulates granule cell migration in the developing hippocampus. Hum Mol Genet, 18:3286-97. (PubMed:19502360)
  9. Muhlhans J et al. (2011) The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors. PLoS One, 6:e26496. (PubMed:22031837)
  10. Park YU et al. (2010) Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. Proc Natl Acad Sci U S A, 107:17785-90. (PubMed:20880836)
  11. Singh KK et al. (2010) Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron, 67:33-48. (PubMed:20624590)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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