Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Txndc2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Txndc2
  • performs the following molecular functions:
    • protein disulfide isomerase activity ^[1]
  • is located in the following cellular components:
    • microtubule-based flagellum ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Txndc2:
  • participates in the following biological processes:
    • oxidation-reduction process
  • performs the following molecular functions:
    • thioredoxin-disulfide reductase activity
  • is located in the following cellular components:
    • cytoplasm
    • nucleolus
    • nucleus
    • outer dense fiber

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Summary text based on GO annotations supported by structural data

• Txndc2 encodes a protein or proteins that contain the following InterPro domains: Thioredoxin, Thioredoxin domain, Thioredoxin-like fold, indicating that the gene product:
  • participates in the following biological processes:
    • cell redox homeostasis
    • glycerol ether metabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • electron carrier activity
    • protein disulfide oxidoreductase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Txndc2 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • spermatogenesis

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References

1. Jimenez A et al. (2002) Cloning, expression and characterization of mouse spermatid specific thioredoxin-1 gene and protein. Mol Hum Reprod, 8:710-8. (PubMed:12149401)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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