GO curators for mouse genes have assigned the following annotations to the gene product of Eif2b1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 22, 2006. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.Summary from NCBI RefSeq
[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009]Summary text based on GO annotations supported by experimental evidence in mouse
The gene product of Eif2b1 has been shown to bind to the gene products of Crebbp. [1]
Summary text based on GO annotations supported by experimental evidence in other organisms
From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Eif2b1:
participates in the following biological processes:
Yin X et al. (2005) Identification of novel CBP interacting proteins in embryonic orofacial tissue. Biochem Biophys Res Commun, 329:1010-7. (PubMed:15752756)
Analysis Tools
Text File
Excel File