Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleoplasm and site of DNA damage. Predicted to colocalize with site of double-strand break. Human ortholog(s) of this gene implicated in Fanconi anemia. Orthologous to human RFWD3 (ring finger and WD repeat domain 3).