Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable protein heterodimerization activity; ubiquitin activating enzyme activity; and ubiquitin protein ligase binding activity. Predicted to contribute to NEDD8 activating enzyme activity. Predicted to be involved in several processes, including mitotic DNA replication checkpoint signaling; protein modification by small protein conjugation; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in early endosome. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; heart; and retina. Orthologous to human NAE1 (NEDD8 activating enzyme E1 subunit 1).