Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables interleukin-1 receptor binding activity. Acts upstream of or within cytokine-mediated signaling pathway. Predicted to be located in extracellular space. Predicted to be active in several cellular components, including cell surface; nucleus; and plasma membrane. Is expressed in aorta-gonad-mesonephros; central nervous system; liver; retina; and ureteric trunk. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4).