Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables chromatin DNA binding activity. Involved in several processes, including alpha-beta T cell lineage commitment; positive regulation of DNA demethylation; and regulation of positive thymic T cell selection. Acts upstream of or within hematopoietic or lymphoid organ development; lymphocyte differentiation; and positive regulation of natural killer cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human TOX (thymocyte selection associated high mobility group box).