Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc6a20a. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc6a20a
  • participates in the following biological processes:
    • amino acid transmembrane transport ^[1]
    • amino acid transport ^[1]
  • performs the following molecular functions:
    • amino acid transmembrane transporter activity ^[1]
  • is located in the following cellular components:
    • apical plasma membrane ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc6a20a:
  • participates in the following biological processes:
    • amino acid transmembrane transport
    • amino acid transport
    • glycine transport
    • proline transport
  • performs the following molecular functions:
    • amino acid transmembrane transporter activity

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Summary text based on GO annotations supported by structural data

• Slc6a20a encodes a protein or proteins that contain the following InterPro domains: Sodium:neurotransmitter symporter, Sodium:neurotransmitter symporter, orphan, indicating that the gene product:
  • participates in the following biological processes:
    • neurotransmitter transport
  • performs the following molecular functions:
    • neurotransmitter:sodium symporter activity
  • is located in the following cellular components:
    • integral to membrane
    • integral to plasma membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc6a20a indicates that it:
  • participates in the following biological processes:
    • transport
  • performs the following molecular functions:
    • symporter activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Kowalczuk S et al. (2005) Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter. Biochem J, 386:417-22. (PubMed:15689184)
2. Romeo E et al. (2006) Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus. Am J Physiol Renal Physiol, 290:F376-83. (PubMed:16174864)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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