Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mbd5. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 5, 2013. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mbd5
  • participates in the following biological processes:
    • glucose homeostasis ^[1]
    • positive regulation of growth hormone receptor signaling pathway ^[1]
    • regulation of multicellular organism growth ^[1]

---

Summary text based on GO annotations supported by structural data

• Mbd5 encodes a protein or proteins that contain the following InterPro domains: Methyl-CpG DNA binding, indicating that the gene product:
  • performs the following molecular functions:
    • DNA binding
  • is located in the following cellular components:
    • nucleus

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mbd5 indicates that it:
  • is located in the following cellular components:
    • chromosome
    • nucleus
• Annotations directly to for the gene Mbd5 indicate that MGI curators have found no experimental data [literature] to support further annotation to these categories at this time.

---

References

1. Du Y et al. (2012) The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. PLoS One, 7:e47358. (PubMed:23077600)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---