Automated description from the Alliance of Genome Resources (Release 3.2)
Involved in several processes, including Wnt signaling pathway, planar cell polarity pathway; animal organ development; and plasma membrane bounded cell projection organization. Localizes to several cellular components, including COPII-coated ER to Golgi transport vesicle; lateral plasma membrane; and stress fiber. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system epithelium; and sensory organ. Used to study neural tube defect. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2).