Automated description from the Alliance of Genome Resources (Release 5.2.0)
Involved in axon guidance; cell migration involved in kidney development; and morphogenesis of an epithelium. Acts upstream of or within several processes, including heart morphogenesis; inner ear development; and morphogenesis of an epithelium. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and stress fiber. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; neural ectoderm; and sensory organ. Used to study neural tube defect. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2).