Automated description from the Alliance of Genome Resources
Exhibits sodium channel inhibitor activity and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of systemic arterial blood pressure; regulation of bicellular tight junction assembly; and regulation of ion transport. Predicted to colocalize with the plasma membrane. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb segment; and retina. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase).