Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Erap1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Erap1
  • participates in the following biological processes:
    • metabolic process ^[1]
  • performs the following molecular functions:
    • aminopeptidase activity ^[1]
  • is located in the following cellular components:
    • cytoplasm ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Erap1
  • participates in the following biological processes:
    • positive regulation of angiogenesis ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Erap1:
  • participates in the following biological processes:
    • membrane protein ectodomain proteolysis
    • proteolysis
  • performs the following molecular functions:
    • aminopeptidase activity
    • interleukin-6 receptor binding
    • metalloexopeptidase activity
    • tumor necrosis factor receptor binding
    • zinc ion binding
  • is located in the following cellular components:
    • endoplasmic reticulum lumen
    • extracellular region
    • intracellular membrane-bounded organelle

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Summary text based on GO annotations supported by structural data

• Erap1 encodes a protein or proteins that contain the following InterPro domains: Domain of unknown function DUF3358, Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase, Peptidase M1, membrane alanine aminopeptidase, N-terminal, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • metallopeptidase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Erap1 indicates that it:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding
    • metallopeptidase activity
    • peptidase activity
  • is located in the following cellular components:
    • endoplasmic reticulum
    • integral to membrane
    • membrane

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References

1. Miyashita H et al. (2002) A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis. Blood, 99:3241-9. (PubMed:11964289)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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