Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Il23a. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Il23a
  • participates in the following biological processes:
    • positive regulation of defense response to virus by host ^[2]
    • positive regulation of memory T cell differentiation ^[2]
    • positive regulation of neutrophil chemotaxis ^[3]
    • positive regulation of T cell mediated cytotoxicity ^[2]
    • positive regulation of T-helper 1 type immune response ^[2]
    • positive regulation of T-helper 17 cell lineage commitment ^[5]
    • positive regulation of T-helper 17 type immune response ^[5]
    • T cell proliferation ^[4]
  • is located in the following cellular components:
    • extracellular space ^[7]
• The gene product of Il23a has been shown to bind to the gene products of Il12b. ^[6] Researchers have inferred, based on physical interactions, that the gene product of Il23a
  • performs the following molecular functions:
    • interleukin-23 receptor binding ^[6]
• Researchers have inferred, based on genetic interactions, that the gene product of Il23a
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Il1a, Il1b ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Il23a:
  • participates in the following biological processes:
    • defense response to Gram-negative bacterium
    • negative regulation of interleukin-10 production
    • positive regulation of activated T cell proliferation
    • positive regulation of activation of JAK2 kinase activity
    • positive regulation of defense response to virus by host
    • positive regulation of granulocyte macrophage colony-stimulating factor production
    • positive regulation of interferon-gamma production
    • positive regulation of interleukin-10 production
    • positive regulation of interleukin-12 production
    • positive regulation of interleukin-17 production
    • positive regulation of natural killer cell proliferation
    • positive regulation of NK T cell activation
    • positive regulation of NK T cell proliferation
    • positive regulation of osteoclast differentiation
    • positive regulation of T cell proliferation
    • positive regulation of T-helper 1 type immune response
    • positive regulation of tumor necrosis factor production
    • positive regulation of tyrosine phosphorylation of Stat3 protein
    • positive regulation of tyrosine phosphorylation of Stat4 protein
    • positive regulation of tyrosine phosphorylation of Stat5 protein
    • regulation of tyrosine phosphorylation of Stat1 protein
  • performs the following molecular functions:
    • interleukin-23 receptor binding
  • is located in the following cellular components:
    • interleukin-23 complex

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Summary text based on GO annotations supported by structural data

• Il23a encodes a protein or proteins that contain the following InterPro domains: Four-helical cytokine, core, Four-helical cytokine-like, core, Interleukin 23 alpha subunit p19, Interleukin-6/G-CSF/MGF, indicating that the gene product:
  • participates in the following biological processes:
    • immune response
  • performs the following molecular functions:
    • cytokine activity
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Il23a indicates that it:
  • participates in the following biological processes:
    • defense response to virus
    • immune system process
    • inflammatory response
    • innate immune response
    • tissue remodeling
  • performs the following molecular functions:
    • cytokine activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Guo L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A, 106:13463-8. (PubMed:19666510)
2. Ha SJ et al. (2004) IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization. J Immunol, 172:525-31. (PubMed:14688363)
3. Lemos HP et al. (2009) Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc Natl Acad Sci U S A, 106:5954-9. (PubMed:19289819)
4. Liang SC et al. (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med, 203:2271-9. (PubMed:16982811)
5. Morishima N et al. (2009) TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23. Biochem Biophys Res Commun, 386:105-10. (PubMed:19501566)
6. Oppmann B et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity, 13:715-25. (PubMed:11114383)
7. Wolf R et al. (2010) Gene from a psoriasis susceptibility locus primes the skin for inflammation. Sci Transl Med, 2:61ra90. (PubMed:21148126)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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