Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ift122. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of January 2, 2013. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ift122
  • is located in the following cellular components:
    • cytoplasm ^[6]
    • photoreceptor connecting cilium ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ift122
  • participates in the following biological processes:
    • camera-type eye morphogenesis ^[1]
    • cilium morphogenesis ^[1]
    • dorsal/ventral pattern formation ^[2]
    • embryonic body morphogenesis ^[1]
    • embryonic digit morphogenesis ^[2]
    • embryonic heart tube development ^[1]
    • limb development ^[1]
    • neural tube closure ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Ift122
  • participates in the following biological processes:
    • ciliary receptor clustering involved in smoothened signaling pathway based on interactions with Wdr19 ^[4]
    • cilium morphogenesis based on interactions with Wdr19 ^[4]
    • dorsal/ventral pattern formation based on interactions with Shh ^[5]
    • smoothened signaling pathway involved in dorsal/ventral neural tube patterning based on interactions with Wdr19 ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ift122:
  • is located in the following cellular components:
    • cytoplasm

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ift122 indicates that it:
  • participates in the following biological processes:
    • cell projection organization
    • multicellular organismal development
  • is located in the following cellular components:
    • cell projection
    • cilium
    • cytoskeleton
• Annotations directly to molecular function for the gene Ift122 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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References

1. Cortellino S et al. (2009) Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4. Dev Biol, 325:225-37. (PubMed:19000668)
2. Garcia-Garcia MJ et al. (2005) Inaugural Article: Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A, 102:5913-9. (PubMed:15755804)
3. Jiang ST et al. (2009) Essential Role of Nephrocystin in Photoreceptor Intraflagellar Transport in Mouse. Hum Mol Genet, null:null. (PubMed:19208653)
4. Liem KF Jr et al. (2012) The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J Cell Biol, 197:789-800. (PubMed:22689656)
5. Ocbina PJ et al. (2011) Complex interactions between genes controlling trafficking in primary cilia. Nat Genet, 43:547-53. (PubMed:21552265)
6. Qin J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc Natl Acad Sci U S A, 108:1456-61. (PubMed:21209331)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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