Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dpys. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of May 3, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on physical interactions, that the gene product of Dpys
  • performs the following molecular functions:
    • phosphoprotein binding ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Dpys:
  • participates in the following biological processes:
    • beta-alanine metabolic process
    • protein homooligomerization
    • protein homotetramerization
    • pyrimidine nucleobase catabolic process
    • thymine catabolic process
    • uracil catabolic process
    • uracil metabolic process
  • performs the following molecular functions:
    • amino acid binding
    • dihydropyrimidinase activity
    • thymine binding
    • uracil binding
    • zinc ion binding
  • is located in the following cellular components:
    • cytosol

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Summary text based on GO annotations supported by structural data

• Dpys encodes a protein or proteins that contain the following InterPro domains: Amidohydrolase 1, Hydantoinase/dihydropyrimidinase, Metal-dependent hydrolase, composite domain, indicating that the gene product:
  • performs the following molecular functions:
    • hydrolase activity
    • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
  • is located in the following cellular components:
    • cytoplasm

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Dpys indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding

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References

1. Fukada M et al. (2000) Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family J Biol Chem, 275:37957-65. (PubMed:10956643)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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