Automated description from the Alliance of Genome Resources
Exhibits NAD-dependent histone deacetylase activity (H3-K14 specific) and sequence-specific DNA binding activity. Involved in negative regulation of peptidyl-lysine acetylation; peptidyl-lysine deacetylation; and positive regulation of cellular biosynthetic process. Localizes to the mitochondrial inner membrane; mitochondrial matrix; and protein-containing complex. Used to study abdominal obesity-metabolic syndrome. Is expressed in several structures, including brain; branchial arch; endocrine gland; genitourinary system; and liver and biliary system. Orthologous to human SIRT3 (sirtuin 3).