Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables NAD-dependent protein deacetylase activity and sequence-specific DNA binding activity. Involved in positive regulation of ceramide biosynthetic process and positive regulation of mitochondrial transcription. Acts upstream of or within negative regulation of peptidyl-lysine acetylation. Located in mitochondrial inner membrane and mitochondrial matrix. Part of protein-containing complex. Is expressed in several structures, including brain; branchial arch; endocrine gland; genitourinary system; and liver and biliary system. Used to study abdominal obesity-metabolic syndrome. Orthologous to human SIRT3 (sirtuin 3).