Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Trpv4. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Trpv4
  • participates in the following biological processes:
    • calcium ion import ^[6]
    • cellular hypotonic response ^[6]
    • osmosensory signaling pathway ^{[3, 6]}
    • response to osmotic stress ^[3]
  • performs the following molecular functions:
    • calcium channel activity ^{[3, 4, 6]}
    • osmosensor activity ^[3]
  • is located in the following cellular components:
    • adherens junction ^[2]
    • cilium ^[5]
    • plasma membrane ^{[2, 4, 6]}
• The gene product of Trpv4 has been shown to bind to the gene products of Ctnnb1. ^{[2, 4]} Researchers have inferred, based on physical interactions, that the gene product of Trpv4
  • participates in the following biological processes:
    • response to osmotic stress ^[4]
  • performs the following molecular functions:
    • protein kinase binding ^[6]
    • SH2 domain binding ^[6]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Trpv4
  • participates in the following biological processes:
    • cell-cell junction assembly ^[2]
    • hyperosmotic salinity response ^[1]
    • osmosensory signaling pathway ^[1]
    • regulation of response to osmotic stress ^[1]
    • vasopressin secretion ^[1]
  • performs the following molecular functions:
    • osmosensor activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Trpv4:
  • participates in the following biological processes:
    • actin cytoskeleton reorganization
    • actin filament organization
    • calcium ion import
    • calcium ion transport
    • cellular calcium ion homeostasis
    • cortical microtubule organization
    • elevation of cytosolic calcium ion concentration
    • hypotonic response
    • microtubule polymerization
    • negative regulation of neuron projection development
    • positive regulation of microtubule depolymerization
  • performs the following molecular functions:
    • actin binding
    • actin filament binding
    • alpha-tubulin binding
    • beta-tubulin binding
    • calcium channel activity
    • calmodulin binding
    • cation channel activity
    • microtubule binding
    • protein kinase binding
    • protein kinase C binding
  • is located in the following cellular components:
    • cell surface
    • cortical actin cytoskeleton
    • cytoplasmic microtubule
    • cytoplasmic vesicle
    • filopodium
    • focal adhesion
    • growth cone
    • lamellipodium
    • plasma membrane
    • ruffle membrane

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Summary text based on GO annotations supported by structural data

• Trpv4 encodes a protein or proteins that contain the following InterPro domains: Ankyrin repeat, Ankyrin repeat-containing domain, Ion transport domain, Transient receptor potential channel, Transient receptor potential channel, vanilloid, Transient receptor potential channel, vanilloid 1-4, Transient receptor potential channel, vanilloid 4, indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
    • transmembrane transport
  • performs the following molecular functions:
    • ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Trpv4 indicates that it:
  • participates in the following biological processes:
    • calcium ion transmembrane transport
    • ion transport
    • transport
  • performs the following molecular functions:
    • ATP binding
    • nucleotide binding
  • is located in the following cellular components:
    • cell junction
    • integral to membrane
    • membrane

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References

1. Mizuno A et al. (2003) Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol, 285:C96-101. (PubMed:12777254)
2. Sokabe T et al. (2010) The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem, 285:18749-58. (PubMed:20413591)
3. Strotmann R et al. (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity Nat Cell Biol, 2:695-702. (PubMed:11025659)
4. Suzuki M et al. (2003) Microfilament-associated protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J Biol Chem, 278:51448-53. (PubMed:14517216)
5. Teilmann SC et al. (2005) Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev, 71:444-52. (PubMed:15858826)
6. Xu H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem, 278:11520-7. (PubMed:12538589)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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