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Gene Ontology Classifications
Symbol
Name
ID
Trpv4
transient receptor potential cation channel, subfamily V, member 4
MGI:1926945

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Trpv4. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. D'hoedt D et al. (2008) Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. J Biol Chem, 283:6272-80. (PubMed:18174177)
  2. Mizuno A et al. (2003) Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol, 285:C96-101. (PubMed:12777254)
  3. Sokabe T et al. (2010) The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem, 285:18749-58. (PubMed:20413591)
  4. Strotmann R et al. (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity Nat Cell Biol, 2:695-702. (PubMed:11025659)
  5. Suzuki M et al. (2003) Microfilament-associated protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J Biol Chem, 278:51448-53. (PubMed:14517216)
  6. Teilmann SC et al. (2005) Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev, 71:444-52. (PubMed:15858826)
  7. Wegierski T et al. (2006) The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels. EMBO J, 25:5659-69. (PubMed:17110928)
  8. Xu H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem, 278:11520-7. (PubMed:12538589)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory