Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables L-asparagine, sodium:proton antiporter activity; L-glutamine, sodium:proton antiporter activity; and L-histidine, sodium:proton antiporter activity. Involved in amino acid transport and intracellular amino acid homeostasis. Acts upstream of or within amino acid transport; cellular response to potassium ion starvation; and positive regulation of transcription by RNA polymerase II. Located in apical plasma membrane. Is expressed in several structures, including central nervous system; metanephros; pancreas; pericardium; and retina. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 102. Orthologous to human SLC38A3 (solute carrier family 38 member 3).