Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rsph9. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein thought to be a component of the radial spoke head in motile cilia and flagella. Mutations in this gene are associated with primary ciliary dyskinesia 12. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on genetic interactions, that the gene product of Rsph9
  • participates in the following biological processes:
    • cilium axoneme assembly based on interactions with ^[1]
    • cilium movement based on interactions with ^[1]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Rsph9
  • is located in the following cellular components:
    • cilium axoneme ^[1]
    • motile cilium ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rsph9:
  • participates in the following biological processes:
    • cilium axoneme assembly
    • cilium movement

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rsph9 indicates that it:
  • is located in the following cellular components:
    • cell projection
    • cilium
    • cytoplasm
    • cytoskeleton
• Annotations directly to molecular function for the gene Rsph9 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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References

1. Castleman VH et al. (2009) Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities. Am J Hum Genet, 84:197-209. (PubMed:19200523)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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