Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Atp13a2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Atp13a2:
  • is located in the following cellular components:
    • lysosome

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Summary text based on GO annotations supported by structural data

• Atp13a2 encodes a protein or proteins that contain the following InterPro domains: ATPase, P-type, cytoplasmic transduction domain A, ATPase, cation-transporting, domain N, ATPase, P-type cation-transporter, N-terminal, ATPase, P-type phosphorylation site, ATPase, P-type, ATPase-associated domain, ATPase, P-type, cytoplasmic domain N, ATPase, P-type, H+ transporting proton pump, ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter, ATPase, P-type, unknown pump specificity (type V), HAD-like domain, indicating that the gene product:
  • participates in the following biological processes:
    • cation transport
  • performs the following molecular functions:
    • ATPase activity
    • cation-transporting ATPase activity
    • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    • metal ion binding
    • nucleotide binding
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Atp13a2 indicates that it:
  • performs the following molecular functions:
    • ATP binding
    • hydrolase activity
    • metal ion binding
    • nucleotide binding
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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