Automated description from the Alliance of Genome Resources (Release 3.1.1)
Predicted to have BMP binding activity and transcription factor binding activity. Involved in negative regulation of ossification; negative regulation of signal transduction; and ossification. Predicted to localize to Golgi apparatus; extracellular space; and protein-containing complex. Is expressed in several structures, including arterial system; jaw; limb; nervous system; and skeleton. Used to study SOST-related sclerosing bone dysplasia and sclerosteosis 1. Human ortholog(s) of this gene implicated in SOST-related sclerosing bone dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin).