Automated description from the Alliance of Genome Resources (Release 5.2.2)
Predicted to enable BMP binding activity and DNA-binding transcription factor binding activity. Acts upstream of or within negative regulation of ossification; negative regulation of signal transduction; and ossification. Predicted to be located in Golgi apparatus. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Is expressed in several structures, including arterial system; jaw; limb bud; nervous system; and skeleton. Used to study SOST-related sclerosing bone dysplasia and sclerosteosis 1. Human ortholog(s) of this gene implicated in SOST-related sclerosing bone dysplasia; autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin).